We study fundamental properties of synaptic transmission, how these properties are modified by experience, and how best to control neuronal activity for making nervous systems more efficient. In our primary area of focus, we are developing novel methods for the control of neuronal activity in intact brain circuits. To this end, we have been engineering methods, devices, and applications for the use of pulsed ultrasound in the noninvasive remote control of brain activity. We expect our work to provide a backbone for the design and implementation of brain stimulation therapies useful in managing a host of neurological diseases. Due to its noninvasive nature and other physical characteristics, pulsed ultrasound also provides an ideal source of energy for achieving brain stimulation in future brain-machine interfaces. See the Ultrasonic Neuromodulation link at left for further information. In a second set of investigations, we aim to better understand the manner by which natural activity patterns modify the strengths of sensory inputs. Here, we focus on primary sensory circuits in the rodent olfactory system to study experience-mediated changes in sensory input gains and how these gains trigger differential behavioral outputs in a context-dependent manner. See the Synaptic Plasticity link at left for further information. | ScienceDaily: Mind & Brain News |
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